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Scenario A: The "Dirty" Cut or Surface Injury Imagine you fall off your mountain bike and get a nasty scrape, or you have an open wound that has a high chance of becoming irritated or infected

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But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance Stick to researched dosing windows (typically 1020 mg/day for short cycles in animal models) 2

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Energy benefits, especially in B12-depleted patients, are often felt within the first 1 to 2 weeks